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April 2026 Central America & Panama Canal Cruises
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Showing 1 - 10 of 46 Cruises
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7 Night Central America & Panama Canal Cruise from Colon, Panama
Windstar Cruises Star Seeker
Departure Port:
Colon, Panama
OCG Class
Luxury
Cruises to: Balboa / Fuerte Amador; Balboa / Fuerte Amador; Quepos; Puerto Caldera
Departing
Interior
Oceanview
Balcony
Suite
Apr 13, 2026
-
$4,099
-
$4,399
Add to Compare
8 Night Central America & Panama Canal Cruise from Puerto Caldera, Costa Rica
Windstar Cruises Star Seeker
Departure Port:
Puerto Caldera, Costa Rica
OCG Class
Luxury
Cruises to: Curú, Costa Rica; Playas del Coco; Puerto Chiapas; Huatulco; Manzanillo; Puerto Vallarta
Departing
Interior
Oceanview
Balcony
Suite
Apr 20, 2026
-
$3,799
-
$4,099
Add to Compare
10 Night Central America & Panama Canal Cruise from Colon, Panama
Royal Caribbean International Serenade of the Seas
Departure Port:
Colon, Panama
OCG Class
Mainstream
Cruises to: PUNTARENAS, COSTA RICA; PUERTO VALLARTA, MEXICO; LOS ANGELES, CALIFORNIA
Departing
Interior
Oceanview
Balcony
Suite
Apr 25, 2026
$542
$841
$1,255
$2,159
Add to Compare
10 Night Central America & Panama Canal Cruise from Miami, FL
Oceania Cruises Insignia
Departure Port:
Miami, FL
OCG Class
Premium
Cruises to: COZUMEL; COSTA MAYA; BELIZE CITY; ROATAN; COLON; PANAMA CITY; PANAMA CITY
Departing
Interior
Oceanview
Balcony
Suite
Apr 14, 2026
$1,570
$1,840
$3,280
$5,080
Add to Compare
10 Night Central America & Panama Canal Cruise from Panama City, Panama
Oceania Cruises Insignia
Departure Port:
Panama City, Panama
OCG Class
Premium
Cruises to: CARTAGENA; WILLEMSTAD; ORANJESTAD; MONTEGO BAY; GEORGE TOWN; MIAMI
Departing
Interior
Oceanview
Balcony
Suite
Apr 4, 2026
$2,020
$2,420
$3,920
$6,220
Add to Compare
10 Night Central America & Panama Canal Cruise from Panama City, Panama
Oceania Cruises Insignia
Departure Port:
Panama City, Panama
OCG Class
Premium
Cruises to: CARTAGENA; ROATAN; COSTA MAYA; COZUMEL; MIAMI
Departing
Interior
Oceanview
Balcony
Suite
Apr 24, 2026
$1,954
$2,254
$3,854
$5,854
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
Add to Compare
13 Night Central America & Panama Canal Cruise from Miami, FL
MSC Cruises MSC Poesia
Departure Port:
Miami, FL
OCG Class
Mainstream
Cruises to: Cartagena Colombia; Colon Panama; Puntarenas (san José) Costa Rica; Cabo San Lucas Mexico; San Diego Usa
Departing
Interior
Oceanview
Balcony
Suite
Apr 23, 2026
Contact cruise line for pricing & availability
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